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1

P-glycoprotein in the placenta: Expression, localization, regulation and function

Martina Ceckova-Novotna, Petr Pavek, Frantisek Staud

Journal:

Reproductive Toxicology

Year:

2006

Language:

english

File:

PDF, 1.07 MB

english, 2006

2

Stereoselective pharmacokinetics of flobufen in rats

Frantisek Trejtnar, Vladimir Wsol, Barbora Szotakova, Lenka Skalova, Petr Pavek, Miroslav Kuchar

Journal:

Year:

1999

Language:

english

File:

PDF, 101 KB

english, 1999

3

Stereoselective pharmacokinetics and metabolism of flobufen in guinea pigs

František Trejtnar, Radim Král, Petr Pávek, Vladimír Wsól

Journal:

Year:

2003

Language:

english

File:

PDF, 105 KB

english, 2003

4

New high-performance liquid chromatography method for the determination of (R)-warfarin and (S)-warfarin using chiral separation on a glycopeptide-based stationary phase

Jana Malakova, Petr Pavek, Lucie Svecova, Iveta Jokesova, Pavel Zivny, Vladimir Palicka

Journal:

Journal of Chromatography B

Year:

2009

Language:

english

File:

PDF, 282 KB

english, 2009

5

EXPRESSION AND FUNCTIONAL ACTIVITY OF BREAST CANCER RESISTANCE PROTEIN (BCRP, ABCG2) TRANSPORTER IN THE HUMAN CHORIOCARCINOMA CELL LINE BEWO

Martina Ceckova, Antonin Libra, Petr Pavek, Petr Nachtigal, Marianne Brabec, Renate Fuchs, Frantisek Staud

Journal:

Clinical and Experimental Pharmacology and Physiology

Year:

2006

Language:

english

File:

PDF, 228 KB

english, 2006

6

Lack of Interactions between Breast Cancer Resistance Protein (BCRP/ABCG2) and Selected Antiepileptic Agents

Lukas Cerveny, Petr Pavek, Jana Malakova, Frantisek Staud, Zdenek Fendrich

Journal:

Year:

2006

Language:

english

File:

PDF, 292 KB

english, 2006

7

JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon receptor and induces CYP1A1 and CYP1A2 genes in primary human hepatocytes

Zdenek Dvorak, Radim Vrzal, Pavla Henklova, Petra Jancova, Eva Anzenbacherova, Patrick Maurel, Lucie Svecova, Petr Pavek, Jiri Ehrmann, Roman Havlik, Petr Bednar, Karel Lemr, Jitka Ulrichova

Journal:

Biochemical Pharmacology

Year:

2008

Language:

english

File:

PDF, 828 KB

english, 2008

8

Intestinal cell-specific vitamin D receptor (VDR)-mediated transcriptional regulation of CYP3A4 gene

Petr Pavek, Katerina Pospechova, Lucie Svecova, Zdenka Syrova, Lucie Stejskalova, Jana Blazkova, Zdenek Dvorak, Jaroslav Blahos

Journal:

Biochemical Pharmacology

Year:

2010

Language:

english

File:

PDF, 657 KB

english, 2010

9

Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene

Lucie Krausova, Lucie Stejskalova, Hongwei Wang, Radim Vrzal, Zdenek Dvorak, Sridhar Mani, Petr Pavek

Journal:

Biochemical Pharmacology

Year:

2011

Language:

english

File:

PDF, 1015 KB

english, 2011

10

Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes

Radim Vrzal, Lucie Stejskalova, Katalin Monostory, Patrick Maurel, Petr Bachleda, Petr Pavek, Zdenek Dvorak

Journal:

Chemico-Biological Interactions

Year:

2009

Language:

english

File:

PDF, 824 KB

english, 2009

11

SB203580, a pharmacological inhibitor of p38 MAP kinase transduction pathway activates ERK and JNK MAP kinases in primary cultures of human hepatocytes

Pavla Henklova, Radim Vrzal, Barbora Papouskova, Petr Bednar, Petra Jancova, Eva Anzenbacherova, Jitka Ulrichova, Patrick Maurel, Petr Pavek, Zdenek Dvorak

Journal:

European Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 918 KB

english, 2008

12

Construction and characterization of hepatocyte nuclear factor HNF4alpha1 over-expressing cell line derived from human hepatoma HepG2 cells

Aneta Novotna, Aneta Doricakova, Radim Vrzal, Petr Pavek, Zdenek Dvorak

Journal:

European Journal of Pharmacology

Year:

2011

Language:

english

File:

PDF, 1.26 MB

english, 2011

13

Investigation of Orlistat effects on PXR activation and CYP3A4 expression in primary human hepatocytes and human intestinal LS174T cells

Aneta Novotna, Aneta Doricakova, Radim Vrzal, Patrick Maurel, Petr Pavek, Zdenek Dvorak

Journal:

European Journal of Pharmaceutical Sciences

Year:

2010

Language:

english

File:

PDF, 222 KB

english, 2010

14

Comment on “The role of redox-sensitive transcription factors NF-kB and AP-1 in the modulation of the Cyp1A1 gene by mercury, lead, and copper”

Zdenek Dvorak, Petr Pavek

Journal:

Free Radical Biology and Medicine

Year:

2008

Language:

english

File:

PDF, 109 KB

english, 2008

15

RANTES, MCP-1 chemokines and factors describing rheumatoid arthritis

Monika Pavkova Goldbergova, Jolana Lipkova, Nikolas Pavek, Jindra Gatterova, Anna Vasku, Miroslav Soucek, Petr Nemec

Journal:

Molecular Immunology

Year:

2012

Language:

english

File:

PDF, 405 KB

english, 2012

16

P-glycoprotein expression and distribution in the rat placenta during pregnancy

Martina Novotna, Antonin Libra, Martin Kopecky, Petr Pavek, Zdenek Fendrich, Vladimir Semecky, Frantisek Staud

Journal:

Reproductive Toxicology

Year:

2004

Language:

english

File:

PDF, 362 KB

english, 2004

17

Transfer of clorazepate and nordiazepam across the umbilically perfused rat term placenta in situ: Comparison with flunitrazepam and diazepam

Petr Pávek, František Štaud, Zdenek Fendrich, Jana Maláková, Vladimír Palicka

Journal:

Year:

1999

Language:

english

File:

PDF, 669 KB

english, 1999

18

Breast cancer resistance protein (BCRP/ABCG2)

Frantisek Staud, Petr Pavek

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2005

Language:

english

File:

PDF, 230 KB

english, 2005

19

Expression and activity of vitamin D receptor in the human placenta and in choriocarcinoma BeWo and JEG-3 cell lines

Katerina Pospechova, Veronika Rozehnal, Lucie Stejskalova, Radim Vrzal, Nada Pospisilova, Gabriela Jamborova, Karen May, Werner Siegmund, Zdenek Dvorak, Petr Nachtigal, Vladimir Semecky, Petr Pavek

Journal:

Molecular and Cellular Endocrinology

Year:

2009

Language:

english

File:

PDF, 1.40 MB

english, 2009

20

Valproic acid augments vitamin D receptor-mediated induction of CYP24 by vitamin D3: A possible cause of valproic acid-induced osteomalacia?

Radim Vrzal, Aneta Doricakova, Aneta Novotna, Petr Bachleda, Michal Bitman, Petr Pavek, Zdenek Dvorak

Journal:

Toxicology Letters

Year:

2011

Language:

english

File:

PDF, 576 KB

english, 2011

21

Novel cell line for assessment of aryl hydrocarbon receptor transcriptional activity

Aneta Novotna, Zdenek Dvorak, Petr Pavek

Journal:

Toxicology Letters

Year:

2012

Language:

english

File:

PDF, 86 KB

english, 2012

22

Construction and characterization of stable transfected hepatocyte-like cells

Zdenek Dvorak, Petr Pavek, Aneta Novotna

Journal:

Toxicology Letters

Year:

2012

Language:

english

File:

PDF, 86 KB

english, 2012

23

The role of residues T248, Y249 and T422 in the function of human pregnane X receptor

Aneta Doricakova, Aneta Novotna, Radim Vrzal, Petr Pavek, Zdenek Dvorak

Journal:

Archives of Toxicology

Year:

2013

Language:

english

File:

PDF, 1010 KB

english, 2013

24

In vitro platelet antiaggregatory properties of 4-methylcoumarins

Macáková, Kateřina, Řeháková, Zuzana, Mladěnka, Přemysl, Karlíčková, Jana, Filipský, Tomáš, Říha, Michal, Prasad, Ashok K., Parmar, Virinder S., Jahodář, Luděk, Pávek, Petr, Hrdina, Radomír, Saso, Luc

Journal:

Year:

2012

Language:

english

File:

PDF, 484 KB

english, 2012

25

Olomoucine II and purvalanol A inhibit ABCG2 transporter in vitro and in situ and synergistically potentiate cytostatic effect of mitoxantrone

Jakub Hofman, Davoud Ahmadimoghaddam, Lenka Hahnova, Petr Pavek, Martina Ceckova, Frantisek Staud

Journal:

Pharmacological Research

Year:

2012

Language:

english

File:

PDF, 988 KB

english, 2012

26

Role of breast cancer resistance protein (Bcrp/Abcg2) in fetal protection during gestation in rat

Lenka Cygalova, Martina Ceckova, Petr Pavek, Frantisek Staud

Journal:

Toxicology Letters

Year:

2008

Language:

english

File:

PDF, 329 KB

english, 2008

27

Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: Investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines

Radim Vrzal, Katerina Kubesova, Petr Pavek, Zdenek Dvorak

Journal:

Toxicology Letters

Year:

2010

Language:

english

File:

PDF, 525 KB

english, 2010

28

Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T

Kamenickova, Alzbeta, Anzenbacherova, Eva, Pavek, Petr, Soshilov, Anatoly A., Denison, Michael S., Anzenbacher, Pavel, Dvorak, Zdenek

Journal:

Toxicology Letters

Year:

2013

Language:

english

File:

PDF, 669 KB

english, 2013

29

Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates

Mandíková, Jana, Volková, Marie, Pávek, Petr, Česnek, Michal, Janeba, Zlatko, Kubíček, Vladimír, Trejtnar, František

Journal:

Year:

2013

Language:

english

File:

PDF, 873 KB

english, 2013

30

Nuclear receptors in regulation of biotransformation enzymes and drug transporters in the placental barrier

Pavek, Petr, Smutny, Tomas

Journal:

Drug Metabolism Reviews

Year:

2014

Language:

english

File:

PDF, 387 KB

english, 2014

31

Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions

Aatsinki, Sanna-Mari, Buler, Marcin, Salomäki, Henriikka, Koulu, Markku, Pavek, Petr, Hakkola, Jukka

Journal:

British Journal of Pharmacology

Year:

2014

Language:

english

File:

PDF, 1.16 MB

english, 2014

32

U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells

Smutny, Tomas, Bitman, Michal, Urban, Michal, Dubecka, Michaela, Vrzal, Radim, Dvorak, Zdeněk, Pavek, Petr

Journal:

Archives of Toxicology

Year:

2014

Language:

english

File:

PDF, 1.14 MB

english, 2014

33

Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α upregulation in primary human hepatocytes

Rulcova, Alice, Krausova, Lucie, Smutny, Tomas, Vrzal, Radim, Dvorak, Zdenek, Jover, Ramiro, Pavek, Petr

Journal:

Pharmacological Reports

Year:

2013

Language:

english

File:

PDF, 1.41 MB

english, 2013

34

Editorial Board

Stejskalová, Lucie, Vrzal, Radim, Rulcová, Alice, Dvořák, Zdeněk, Pávek, Petr

Journal:

Journal of Dairy Science

Year:

1963

Language:

english

File:

PDF, 110 KB

english, 1963

35

Effects of glucocorticoids on cytochrome P450 1A1 (CYP1A1) expression in isolated human placental trophoblast

Stejskalová, Lucie, Vrzal, Radim, Rulcová, Alice, Dvořák, Zdeněk, Pávek, Petr

Journal:

Journal of Applied Biomedicine

Year:

2013

Language:

english

File:

PDF, 453 KB

english, 2013

36

Construction and characterization of a reporter gene cell line for assessment of human glucocorticoid receptor activation

Novotna, Aneta, Pavek, Petr, Dvorak, Zdenek

Journal:

European Journal of Pharmaceutical Sciences

Year:

2012

Language:

english

File:

PDF, 558 KB

english, 2012

37

Dexamethasone accelerates degradation of aryl hydrocarbon receptor (AHR) and suppresses CYP1A1 induction in placental JEG-3 cell line

Stejskalova, Lucie, Rulcova, Alice, Vrzal, Radim, Dvorak, Zdenek, Pavek, Petr

Journal:

Toxicology Letters

Year:

2013

Language:

english

File:

PDF, 1.62 MB

english, 2013

38

Effects of anthocyanins on the AhR–CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines

Kamenickova, Alzbeta, Anzenbacherova, Eva, Pavek, Petr, Soshilov, Anatoly A., Denison, Michael S., Zapletalova, Michaela, Anzenbacher, Pavel, Dvorak, Zdenek

Journal:

Toxicology Letters

Year:

2013

Language:

english

File:

PDF, 1.44 MB

english, 2013

39

1-Substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their isosteric analogs: A new class of selective antitubercular agents active against drug-susceptible and multidrug-resistant mycobacteria

Karabanovich, Galina, Roh, Jaroslav, Smutný, Tomáš, Němeček, Jan, Vicherek, Petr, Stolaříková, Jiřina, Vejsová, Marcela, Dufková, Ida, Vávrová, Kateřina, Pávek, Petr, Klimešová, Věra, Hrabálek, Alexan

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 815 KB

english, 2014

40

Cholestatic effect of epigallocatechin gallate in rats is mediated via decreased expression of Mrp2

Hirsova, Petra, Karlasova, Gabriela, Dolezelova, Eva, Cermanova, Jolana, Zagorova, Marie, Kadova, Zuzana, Hroch, Milos, Sispera, Ludek, Tomsik, Pavel, Lenicek, Martin, Vitek, Libor, Pavek, Petr, Kucer

Journal:

Year:

2013

Language:

english

File:

PDF, 654 KB

english, 2013

41

Novel Stably Transfected Gene Reporter Human Hepatoma Cell Line for Assessment of Aryl Hydrocarbon Receptor Transcriptional Activity: Construction and Characterization

Novotna, Aneta, Pavek, Petr,, Dvorak, Zdenek

Journal:

Environmental Science & Technology

Year:

2011

Language:

english

File:

PDF, 1.48 MB

english, 2011

42

Circulating cytokine pattern and factors describing rheumatoid arthritis: IL-15 as one of the biomarkers for RA?

Pavkova Goldbergova, Monika, Pavek, Nikolas, Lipkova, Jolana, Jarkovsky, Jiri, Stouracova, Martina, Gatterova, Jindra, Vasku, Anna, Soucek, Miroslav, Nemec, Petr

Journal:

Year:

2012

Language:

english

File:

PDF, 994 KB

english, 2012

43

The Association Between Levels of Tissue Inhibitor of Metalloproteinase-1 with Acute Heart Failure and Left Ventricular Dysfunction in Patients with ST Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention

Goldbergova, Monika Pavkova, Parenica, Jiri, Jarkovsky, Jiri, Kala, Petr, Poloczek, Martin, Manousek, Jan, Kluz, Krystyna, Kubkova, Lenka, Littnerova, Simona, Tesak, Martin, Toman, Ondrej, Pavek, Niko

Journal:

Genetic Testing and Molecular Biomarkers

Year:

2012

Language:

english

File:

PDF, 222 KB

english, 2012

44

The impact of C677T and A1298C MTHFR polymorphisms on methotrexate therapeutic response in East Bohemian region rheumatoid arthritis patients

Soukup, Tomas, Dosedel, Martin, Pavek, Petr, Nekvindova, Jana, Barvik, Ivan, Bubancova, Iva, Bradna, Petr, Kubena, Ales Antonin, Carazo, Alejandro Fernández, Veleta, Tomas, Vlcek, Jiri

Journal:

Rheumatology International

Year:

2015

Language:

english

File:

PDF, 392 KB

english, 2015

45

Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR)

Carazo Fernández, Alejandro, Smutny, Tomas, Hyrsová, Lucie, Berka, Karel, Pavek, Petr

Journal:

Toxicology Letters

Year:

2015

Language:

english

File:

PDF, 1.94 MB

english, 2015

46

Boldine enhances bile production in rats via osmotic and Farnesoid X receptor dependent mechanisms

Cermanova, Jolana, Kadova, Zuzana, Zagorova, Marie, Hroch, Milos, Tomsik, Pavel, Nachtigal, Petr, Kudlackova, Zdenka, Pavek, Petr, Dubecka, Michaela, Ceckova, Martina, Staud, Frantisek, Laho, Tomas, M

Journal:

Toxicology and Applied Pharmacology

Year:

2015

Language:

english

File:

PDF, 1.76 MB

english, 2015

47

Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction

Matoulková, Petra, Pávek, Petr, Malý, Josef, Vlček, Jiří

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2014

Language:

english

File:

PDF, 400 KB

english, 2014

48

Xenobiotic-Induced Transcriptional Regulation of Xenobiotic Metabolizing Enzymes of the Cytochrome P450 Superfamily in Human Extrahepatic Tissues

Pavek, Petr, Dvorak, Zdenek

Journal:

Current Drug Metabolism

Year:

2008

Language:

english

File:

PDF, 446 KB

english, 2008

49

The Use of the LanthaScreen TR-FRET CAR Coactivator Assay in the Characterization of Constitutive Androstane Receptor (CAR) Inverse Agonists

Carazo, Alejandro, Pávek, Petr

Journal:

Year:

2015

Language:

english

File:

PDF, 488 KB

english, 2015

50

Bioinformatic analysis of miRNAs targeting the key nuclear receptors regulating CYP3A4 gene expression: The challenge of the CYP3A4 “missing heritability” enigma

Smutny, Tomas, Duintjer Tebbens, Jurjen, Pavek, Petr

Journal:

Journal of Applied Biomedicine

Year:

2015

Language:

english

File:

PDF, 778 KB

english, 2015